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KMID : 0379520090250010017
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한국독성학회지
2009 Volume.25 No. 1 p.17 ~ p.21
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Effects of Aqueous Extract of Schizandra Chinensis Fruit on Cadmium-Induced Change of Monoamine Neurotransmitters in Rats
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Zhao Zheng Lin
Lee Jong-Rok
Zhao Guang Wen
Li Li
Li Meng Quan
Guan Li Xin
Yang Xu Dong
Li Hou Zhong
Lin Feng
Zhao Rong Jie
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Abstract
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The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl2 (0.6 mg/kg/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 mg/kg/d or 60 mg/kg/d, p.o., 30 min before ) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by . These results suggest that AESC ameliorates Cd-induced depletion of monoamine neurotransmitters in brain through its antioxidant activity.
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KEYWORD
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Schizandra Chinensis Fruit, Cadmium, Monoamines, Brain, Rat
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